Eisei Sohara Selected Research

Sodium Chloride Symporters

1/2020	Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease.
1/2019	Tacrolimus ameliorates the phenotypes of type 4 Bartter syndrome model mice through activation of sodium-potassium-2 chloride cotransporter and sodium-chloride cotransporter.
1/2018	Role of ClC-K and barttin in low potassium-induced sodium chloride cotransporter activation and hypertension in mouse kidney.

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Eisei Sohara Research Topics

Disease

24	Pseudohypoaldosteronism 01/2020 - 10/2009
15	Hypertension (High Blood Pressure) 01/2021 - 10/2012
10	Chronic Renal Insufficiency 05/2021 - 03/2012
7	Hyperkalemia 01/2020 - 07/2005
5	Renal Insufficiency (Renal Failure) 06/2022 - 02/2017
5	Nephrogenic Diabetes Insipidus 01/2022 - 09/2006
5	Hypokalemia 01/2022 - 10/2009
5	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 10/2014
4	Gitelman Syndrome 01/2022 - 01/2016
4	Fibrosis (Cirrhosis) 05/2021 - 10/2017
4	Bartter Syndrome (Syndrome, Bartter) 01/2021 - 11/2013
4	Alkalosis 01/2019 - 10/2009
3	Brain Diseases (Brain Disorder) 01/2022 - 01/2015
3	Proteinuria 01/2021 - 11/2013
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020 - 10/2012
3	Acute Kidney Injury (Acute Renal Failure) 11/2019 - 12/2005
3	Hypertrophy 01/2018 - 04/2005
2	Chronic Kidney Failure (Chronic Renal Failure) 06/2022 - 01/2021
2	Inflammation (Inflammations) 05/2021 - 01/2018
2	Polyuria 01/2021 - 01/2019
2	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2021 - 11/2013
2	Autosomal Dominant Polycystic Kidney (ADPKD) 01/2020 - 01/2019
2	Polycystic Kidney Diseases (Polycystic Kidney Disease) 01/2020 - 03/2008
2	Renal hypouricemia 01/2020 - 11/2019
2	Hemorrhage 05/2018 - 01/2018
2	Diabetes Mellitus 01/2018 - 01/2018
2	Sarcopenia 01/2018 - 01/2017
2	Ischemia 08/2006 - 12/2005
1	Hypernatremia 01/2022
1	Hyperaldosteronism (Conn Syndrome) 01/2022
1	Type 2 Diabetes Mellitus (MODY) 01/2022
1	Nail-Patella Syndrome (Syndrome, Nail-Patella) 11/2021
1	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 11/2021
1	Fabry Disease (Fabry's Disease) 11/2021
1	Hypophosphatemia 01/2021
1	Vitamin D Deficiency 01/2021
1	Hyponatremia 01/2021
1	Metabolic Bone Diseases (Osteopenia) 01/2021
1	Hypocalcemia 01/2021
1	Pain (Aches) 01/2021
1	Osteomalacia 01/2021
1	Polydipsia 01/2021

Drug/Important Bio-Agent (IBA)

21	Phosphotransferases (Kinase)IBA 01/2020 - 10/2009
15	Lysine (L-Lysine)FDA Link 01/2020 - 10/2012
13	SaltsIBA 01/2021 - 08/2012
11	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2005
9	SodiumIBA 01/2022 - 10/2012
6	Proline (L-Proline)FDA Link 01/2020 - 10/2012
6	Alanine (L-Alanine)FDA Link 01/2020 - 10/2012
6	PotassiumIBA 01/2020 - 07/2005
5	DiureticsIBA 01/2022 - 01/2016
5	ChloridesIBA 01/2019 - 12/2015
4	Cullin Proteins (Cullins)IBA 01/2020 - 10/2015
3	ElectrolytesIBA 01/2021 - 01/2016
3	Uric Acid (Urate)IBA 01/2020 - 11/2019
3	Pharmaceutical PreparationsIBA 01/2020 - 10/2017
3	Sodium Chloride SymportersIBA 01/2020 - 01/2018
3	CreatinineIBA 11/2019 - 11/2017
3	AntibodiesIBA 06/2019 - 11/2013
3	Vasopressins (Vasopressin)IBA 01/2019 - 11/2016
3	Member 3 Solute Carrier Family 12IBA 01/2019 - 11/2015
3	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 11/2015 - 09/2013
3	Glycerol (Glycerine)FDA LinkGeneric 08/2006 - 04/2005
2	SymportersIBA 01/2022 - 05/2014
2	ReninIBA 01/2022 - 01/2019
2	CollagenIBA 11/2021 - 01/2018
2	LipidsIBA 05/2021 - 05/2018
2	Serum AlbuminIBA 01/2021 - 02/2017
2	Vitamin D FDA LinkGeneric 01/2021 - 06/2017
2	Tolvaptan FDA Link 01/2020 - 01/2019
2	Immunoglobulin G (IgG)IBA 06/2019 - 06/2017
2	Fibrinogen (Factor I)FDA Link 06/2019 - 06/2017
2	Factor XIII (Coagulation Factor XIII)IBA 06/2019 - 06/2017
2	CalciumIBA 01/2019 - 01/2010
2	UbiquitinIBA 01/2018 - 01/2016
2	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA 01/2018 - 01/2017
2	Ligases (Synthetase)IBA 01/2018 - 01/2016
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 12/2015 - 03/2008
2	Cisplatin (Platino)FDA LinkGeneric 08/2006 - 12/2005
2	Biomarkers (Surrogate Marker)IBA 08/2006 - 12/2005
1	dimemorfan (AT 17)IBA 06/2022
1	Vasopressin Receptors (Arginine Vasopressin Receptor)IBA 01/2022
1	GalactosidasesIBA 11/2021
1	Transcription Factors (Transcription Factor)IBA 11/2021
1	Prostaglandin D2IBA 05/2021
1	Collagen Type I (Type I Collagen)IBA 05/2021
1	EnzymesIBA 05/2021
1	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 01/2021
1	Alkaline PhosphataseIBA 01/2021
1	MagnesiumIBA 01/2021
1	Trichlormethiazide (Naqua)FDA Link 01/2021
1	Indomethacin (Indometacin)FDA LinkGeneric 01/2021
1	calcium phosphateIBA 01/2021
1	Drinking WaterIBA 01/2021
1	TransferasesIBA 01/2021
1	catechol (pyrocatechol)IBA 01/2021
1	alfacalcidolIBA 01/2021

Therapy/Procedure

3	Renal Dialysis (Hemodialysis) 01/2021 - 01/2015
2	Protein-Restricted Diet (Diet, Protein Restricted) 01/2019 - 03/2012
2	Sodium-Restricted Diet (Diet, Sodium Restricted) 08/2011 - 10/2009